Showing posts with label cognitive health. Show all posts
Showing posts with label cognitive health. Show all posts

Sunday, 1 February 2026

Guarding Your Independence With Type 2 Diabetes: 7 Risks and Solutions

From everydayhealth.com


Type 2 diabetes doesn’t necessarily lead to a loss of independence on its own. But diabetes complications such as vision loss, muscle weakness, and cognitive decline can make it harder to maintain your quality of life on your own.

Mitigating and avoiding these risks starts with blood sugar control and weight management, but good diabetes management can go a step further. Other solutions can include exercising, sleeping right, and even staying socially active.

1. Risk: Vision Loss

Eyesight can be an essential part of maintaining your quality of life. But poorly managed blood sugar increases your risk of diabetic retinopathy, damage to the blood vessels in your eye’s retina that can lead to vision loss and blindness.

When insulin isn’t working effectively, too much sugar stays in your bloodstream. Over time, this can damage blood vessels throughout the body, says Charles Barron Jr., MD, chief medical officer of Friend Health, a provider for medically underserved communities in Chicago. 

“The eyes have very small blood vessels, and when we can't get blood flow to them, cellular death starts to occur,” Dr. Barron says.

More than 9.5 million people in the United States have diabetic retinopathy, including 26 percent of people with diabetes. It threatens the vision of 1.84 million of those people, about 5 percent of people with diabetes.
About 1 in 14 people with diabetes also develop diabetes-related macular edema, swelling in the macula (the central part of your retina) that can lead to blindness. It is the leading cause of vision loss among people with diabetes, says Jennifer Cheng, MD, chief of endocrinology at Hackensack Meridian Health in Neptune, New Jersey. 

Solution: Get Your Blood Sugar and Blood Pressure Under Control

Managing your blood sugar effectively is key for reducing your risk of diabetes complications, and vision loss is no exception. If you have hypertension, or high blood pressure, lowering your blood pressure could slow the progression of vision issues. Eating healthy foods, exercising regularly, losing excess weight, and taking prescribed medication can help. Injections or lasers can also treat macular edema.

2. Risk: Muscle Weakness (Sarcopenia)

Age-related loss of muscle mass and function, or sarcopenia, affects more than half of people age 80 and older. It can lead to depression, falls, and bone fractures, all of which can reduce your ability to get around on your own.
Type 2 diabetes can speed up this process, which makes it harder for you to control your blood sugar and to be physically active — leading to additional diabetes complications.
In fact, more than 22 percent of people age 50 and older with type 2 diabetes have sarcopenia, compared with 8.8 percent of people who do not have type 2 diabetes. Dr. Cheng says that the following factors contribute to this increased risk of muscle breakdown:
  • Insulin resistance
  • Chronic inflammation
  • Increased accumulation of harmful substances in muscle fibres caused by high blood sugar 
Your risk may be greater if you have the following conditions:
  • High blood pressure
  • Low calcium levels
  • Nerve damage
  • Low amount of physical activity

Solution: Strength-Building Exercise

Regardless of your age, building strength can help maintain muscle mass and manage type 2 diabetes. Two or three resistance-training sessions each week can improve blood sugar control and help your body use insulin efficiently. You don’t even need to go to the gym and use heavy equipment to get results. Barron recommends using a can of food as a dumbbell and performing flexing exercises (think curls or overhead presses) to maintain strength. 

3. Risk: Foot Problems

People with type 2 diabetes have an increased risk of foot issues, from poor circulation to rare and serious conditions such as Charcot foot, that make it difficult or impossible to walk. About 15 percent of people with diabetes get diabetic foot ulcers, usually on the bottom of the foot. Although often preventable, they can lead to amputation in 14 to 24 percent of cases.
Foot issues can be the result of nerve damage or peripheral artery disease, which can reduce blood flow in your feet and can make it harder for foot sores to heal.

“The toes have very small blood vessels, and when circulation is compromised, these areas are particularly vulnerable,” says Barron, adding that doctors typically check your toes and feet for sensation changes and look for evidence of decreased blood flow.

Solution: Daily Foot Care

Wear shoes or socks around the house, and avoid going barefoot or exposing your feet to extreme temperatures, Barron says. Check your feet every day to prevent small problems from becoming large ones. If you develop a foot sore or ulcer, preventing infection by keeping it clean, bandaged, and medicated (when prescribed) is your best bet to avoid complications. Your doctor may refer you to a podiatrist or wound-care specialist for additional treatment.

4. Risk: Severe Hypoglycaemia

Medications that treat type 2 diabetes can lower blood sugar levels, but they can also cause levels to drop too low, known as hypoglycemia. These medications include sulfonylureas and insulin.

Symptoms include hunger, shakiness, and confusion. Though mild cases of hypoglycaemia can be treated with a sugary snack or drink, severe cases of hypoglycaemia cause a risk of losing consciousness, Barron says.

If you are at least 70 years old and have type 2 diabetes, you have an increased risk of being hospitalized for severe hypoglycaemia while taking insulin or sulfonylureas. The risk increases with age.

Solution: More Blood Sugar Testing

Testing blood sugar more frequently helps you make better decisions about medication. Barron says that doctors may monitor your blood sugar levels remotely to gauge blood sugar control more accurately. Continuous glucose monitors give you real-time updates and alarms so you can learn quickly if you have hypoglycaemia.

5. Risk: Chronic Fatigue

“Chronic fatigue is a prevalent and often overlooked symptom in type 2 diabetes, significantly eroding quality of life,” Cheng says. 

This is because high blood sugar from untreated type 2 diabetes affects your ability to convert sugar into energy. The build-up of sugar also causes your kidneys to work harder, leading to frequent urination that can interrupt your sleep.
Being overweight or having obesity can contribute to fatigue, as your body may have to work harder to perform everyday tasks.
Sleep comes into play, as well. People with type 2 diabetes often sleep poorly and wake frequently during the night, Barron says. These sleep issues, including obstructive sleep apnoea and insomnia, can contribute to fatigue.

Solution: Good Sleep Hygiene

Prioritize habits that lead to better sleep:
  • Don't use electronic devices before bed.
  • Exercise during the day.
  • Keep blood sugar and blood pressure levels consistent.
  • Limit daytime naps of more than 30 minutes.
  • Create a comfortable sleep environment, free of light and noise.
In addition, talk to your doctor about getting tested and potentially treated for sleep apnea, a condition in which your airway is completely or partially obstructed during sleep. About 7 in 10 people with type 2 diabetes have obstructive sleep apnoea, which your healthcare team can help you treat.

6. Risk: Cognitive Decline

Losing mental function, such as memory, language, reasoning, and judgment, can limit your ability to do things on your own. Cognitive impairment increases as you age, and it is more common in people with type 2 diabetes, especially those age 65 and older. Risk factors may include obesity, chronic inflammation, and cardiovascular complications of diabetes.
Informally, the progressive brain disorder Alzheimer’s disease is sometimes called type 3 diabetes. The long-term blood sugar problems linked to diabetes may increase the risk of Alzheimer’s and speed memory loss by interfering with how brain cells function.

“Insulin resistance can impair brain cell function and communication,” Cheng says. “If there is not enough sugar in the brain, then there could be damage, especially with severe hypoglycaemia.”

Solution: Brain Stimulation

Maintaining stable blood sugar and staying mentally active can support brain health and functional independence, Barron says. Stimulating activities for your brain include playing cards or board games, learning a new language, trying a new recipe, visiting a new vacation spot, and even planning a dinner party. Trying new things can help your brain form new connections.

7. Risk: Social Isolation

Loneliness can affect quality of life and independence in many ways: Not only can it increase the risk of cognitive decline and conditions such as type 2 diabetes but it also affects mental health — with lonely people being twice as likely to get depressed.
People with type 2 diabetes are especially vulnerable to loneliness and social isolation, with nearly 20 percent of people with the condition also experiencing intense loneliness.

“From a social perspective, people may decline to go out because they feel like they're not going to be able to eat freely, they're embarrassed because they may have to check blood sugar, or [they experience] different social aspects that can impact whether they want to spend time with others,” Barron says. 

People who feel isolated or lonely are more likely to develop diabetes-related problems such as kidney disease, nerve damage, and eye damage than those who are more socially connected. In fact, the risk is about as strong as those associated with smoking, high blood pressure, and low physical activity.

Solution: Explore and Expand Your Community

To get a sense of belonging, take a class to learn something new with others, schedule time each day to stay in touch with family or friends, consider adopting a pet if you can care for one, introduce yourself to your neighbours, or join a community cause to get involved. It's also important to educate your family members and friends about type 2 diabetes so they can help you navigate certain situations, without putting pressure on you to do something you can’t because of the disease, Barron says. 

The Takeaway

  • Effective management of type 2 diabetes, including control of your blood sugar level and weight, can substantially reduce the risk of complications that threaten your independence.
  • If you do not control your blood sugar well, you may risk changes to your vision, muscle mass, and cognitive abilities, as well as foot problems, hypoglycaemia, and fatigue.
  • In addition to good blood sugar control and metabolic health, solutions such as ensuring that your blood pressure is under control, exercising, and even staying socially active can help mitigate risks of complications.
  • Talk to your healthcare team about the best ways to manage your type 2 diabetes and what change you can make to maintain and improve your quality of life.

Friday, 30 August 2024

A healthy lifestyle may counteract diabetes-associated brain ageing

From eurekalert.org

Type 2 diabetes and prediabetes are associated with accelerated brain ageing, according to a new study from Karolinska Institutet in Sweden published in the journal Diabetes Care. The good news is that this may be counteracted by a healthy lifestyle.

Type 2 diabetes is a known risk factor for dementia, but it is unclear how diabetes and its early stages, known as prediabetes, affect brain ageing in people without dementia. Now, a comprehensive brain imaging study shows that both diabetes and prediabetes can be linked to accelerated brain ageing.

The study included more than 31,000 people between 40 and 70 years of age from the UK Biobank who had undergone a brain MRI scan (magnetic resonance imaging). The researchers used a machine learning approach to estimate brain age in relation to the person’s chronological age.

Prediabetes and diabetes were associated with brains that were 0.5 and 2.3 years older than chronological age, respectively. In people with poorly controlled diabetes, the brain appeared more than four years older than chronological age. The researchers also noted that the gap between brain age and chronological age increased slightly over time in people with diabetes. These associations were attenuated among people with high physical activity who abstained from smoking and heavy alcohol consumption.

“Having an older-appearing brain for one’s chronological age can indicate deviation from the normal ageing process and may constitute an early warning sign for dementia,” says the study’s lead author Abigail Dove, a PhD student at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet. “On the positive side, it seems that people with diabetes may be able to influence their brain health through healthy living.”

Repeated MRI data were available for a small proportion of the study participants. Follow-up MRI scans are ongoing and researchers are now continuing to study the association between diabetes and brain ageing over time.

“There’s a high and growing prevalence of type 2 diabetes in the population,” says Abigail Dove. “We hope that our research will help prevent cognitive impairment and dementia in people with diabetes and prediabetes.”

The study was mainly funded by the Swedish Alzheimer’s Foundation, the Dementia Research Fund, the Swedish Research Council and Forte (the Swedish Research Council for Health, Working Life and Welfare). There are no reported conflicts of interest.

Publication: "Diabetes, prediabetes, and brain aging: the role of healthy lifestyle", Abigail Dove, Jiao Wang, Huijie Huang, Michelle M. Dunk, Sakura Sakakibara, Marc Guitart-Masip, Goran Papenberg, Weili Xu, Diabetes Care, online 28 August 2024, doi: 10.2337/dc24-0860 

https://www.eurekalert.org/news-releases/1055727

Wednesday, 22 June 2022

The Relationship Between Diabetes and Dementia

From beingpatient.com

Here’s a primer on how diabetes is linked with dementia risk, and what you can do to reduce your chances of developing the two health conditions

How can a chronic condition originating from the pancreas double your risk of developing Alzheimer’s or dementia? 

According to the Centers for Disease Control and Prevention, more than 30 million Americans are currently living with diabetes. It occurs when cells in the pancreas are unable to produce enough insulin — a hormone that tells the body to import the sugar circulating in the blood into the body. Because sugar is the main source of fuel for the brain, diabetes symptoms can cause fatigue and cognitive impairment. 

When the brain doesn’t get enough energy, it alters its metabolism and leads to cellular damage. These factors may make it more likely that someone with diabetes develops Alzheimer’s disease, or another form of dementia. Additionally, there are many shared risk factors between these two diseases that further explain their close relationship.


Here’s what diabetes and dementia have in common

One of the largest known genetic risk factors for developing Alzheimer’s in certain populations, ApoE4, is also a major risk factor for developing diabetes. This gene encodes a protein that carries cholesterol, increasing blood pressure. While this protein is too large to enter the brain, it is produced by cells called astrocytes and may trigger the release of amyloid plaques.  

Next, high levels of blood sugar which can contribute to the onset of diabetes are also a risk factor for the development of Alzheimer’s and other forms of dementia. 

2013 study, published in the New England Journal of Medicine, found that any abnormal elevations in blood sugar — even in people without diabetes — increased the risk of developing dementia. 

In addition, medications that bring blood glucose under control like metformin are also linked to a reduction in Alzheimer’s risk in people who already have diabetes. 

Black Americans are at an elevated risk of developing diabetes and Alzheimer's. Since the majority of medical research has been conducted on white individuals, studies are seeking to diversify their participants to better understand this risk factor. Meanwhile, poor socioeconomic status which is more common in African American communities is linked to diabetes risk.    

Prevention strategies that work for both diseases

With so many shared risk factors between the two diseases, there is some good news. Many of the same strategies used to prevent diabetes also reduce the risk of developing Alzheimer’s or other forms of dementia. 

A healthy Mediterranean-style diet leads to reductions in cholesterol and blood sugar. Importantly, in the case of brain health, it also means lower risk of developing cognitive impairment. This diet provides a lot of variety in terms of taste, consisting of:

  • Fruits, vegetables, and legumes
  • Nuts and seeds
  • Whole grains
  • Fish, seafood and olive oil

Regular exercise also reduces the risk of developing dementia and helps prevent diabetes. During exercise, there is a reduction in blood sugar levels as the body mobilizes it to fuel the muscles. Exercise also may increase the brain's metabolic rate, staving off cellular damage. 

A combination of healthy eating and exercise can jointly fight against diabetes and Alzheimer’s. As scientists look to better understand the relationship between these two diseases, they come closer to finding new treatments for both.

https://www.beingpatient.com/diabetes-dementia-risk-factor/

Friday, 25 September 2020

Older People Taking Diabetes Drug Show Slower Cognitive Decline

From technologynetworks.com

Metformin is the first-line treatment for most cases of type 2 diabetes and one of the most commonly prescribed medications worldwide, with millions of individuals using it to optimise their blood glucose levels.

A new research study, conducted over six years in the Sydney Memory and Ageing Study in 1037 Australians (aged 70 to 90 years old at baseline), has revealed an additional effect: individuals with type 2 diabetes who used metformin experienced slower cognitive decline with lower dementia rates than those who did not use the medication.

The findings provide new hope for a means of reducing the risk of dementia in individuals with type 2 diabetes, and potentially those without diabetes who number nearly 47 million people worldwide.

The study was led by researchers at the Garvan Institute of Medical Research and the Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, and published in the Journal Diabetes Care.

"We've revealed the promising new potential for a safe and widely used medication, which could be life-changing for patients at risk of dementia and their families. For those with type 2 diabetes, metformin may add something extra to standard glucose lowering in diabetes care: a benefit for cognitive health," says first author Professor Katherine Samaras, Leader of the Healthy Ageing Research Theme at the Garvan Institute and endocrinologist at St Vincent's Hospital Sydney.

Protecting brain function


Type 2 diabetes occurs when the body can no longer produce enough insulin to meet its needs, leaving affected individuals unable to maintain blood glucose levels within a normal range. This can lead to long-term health complications, including cognitive decline.

"As they age, people living with type 2 diabetes have a staggering 60% risk of developing dementia, a devastating condition that impacts thinking, behaviour, the ability to perform everyday tasks and the ability to maintain independence. This has immense personal, family, economic and societal impacts," says Professor Samaras.

The researchers of this study investigated data from participants of CHeBA's Sydney Memory and Ageing Study. In this cohort, 123 study participants had type 2 diabetes, and 67 received metformin to lower blood sugar levels. The researchers tested cognitive function every two years, using detailed assessments that measured cognition over a number of capabilities, including memory, executive function, attention and speed, and language.

The findings revealed individuals with type 2 diabetes taking metformin had significantly slower cognitive decline and lower dementia risk compared to those not taking metformin. Remarkably, in those with type 2 diabetes taking metformin, there was no difference in the rate of decline in cognitive function over 6 years compared to those without diabetes.

New use for a common medication


Metformin has been used safely to treat type 2 diabetes for 60 years. It works by reducing the amount of glucose released from the liver into the blood stream and allows the body's cells to better respond to blood glucose levels.

Studies over the last decade have revealed evidence of metformin's benefit in cancer, heart disease, polycystic ovary syndrome and weight management. While the current study suggests metformin may have cognitive benefits for people living with type 2 diabetes, the researchers say it may also benefit those at risk of cognitive decline more broadly.

"This study has provided promising initial evidence that metformin may protect against cognitive decline. While type 2 diabetes is thought to increase dementia risk by promoting degenerative pathways in the brain and nerves, these pathways also occur in others at risk of dementia and it is possible insulin resistance may be the mediator," says Professor Samaras.

"To establish a definitive effect, we are now planning a large, randomised controlled trial of metformin in individuals at risk of dementia and assess their cognitive function over three years. This may translate to us being able to repurpose this cheap medication with a robust safety profile to assist in preventing against cognitive decline in older people."

CHeBA's Sydney Memory and Ageing Study is an observational study of older Australians that commenced in 2005 and researches the effects of ageing on cognition over time.

Professor Perminder Sachdev, senior author of the study and Co-Director of CHeBA, says: "While an observational study does not provide conclusive 'proof' that metformin is protective against dementia, it does encourage us to study this and other anti-diabetic treatments for dementia prevention. Metformin has even been suggested to be anti-ageing. The intriguing question is whether metformin is helpful in people in those with normal glucose metabolism. More work is clearly needed."