Thursday, 19 February 2026

Can Type 1 diabetes be cured? New treatment shows promise in Ohio

From cleveland.com

CLEVELAND, Ohio — Patients with Type 1 diabetes have lost the specialized pancreatic cells that produce insulin, putting them at risk for dangerous seizures or loss of consciousness due to severe low blood sugar.

But what if their destroyed insulin-producing cells could be replaced by healthy ones?

That’s the idea behind a new treatment, offered at University Hospitals, that infuses insulin-producing islet cells from donated organs into Type 1 diabetic patients with persistent low blood sugar. 

In some patients, the infused cells produce enough insulin that insulin injections are no longer needed, said Dr. Betul Hatipoglu, chief of endocrinology, and medical director of the Diabetes & Metabolic Care Center at UH.

UH is one of the few sites in Ohio offering Lantidra, the most effective and longest lasting treatment that’s been FDA-approved for the more than 2 million Americans with Type 1 diabetes, Hatipoglu said.

The treatment is not for those with Type 2 diabetes, which happens when the body can make its own insulin but allows it to build up in the blood.

In Lantidra clinical trials, about 70% of participants no longer needed insulin after one year. After five years, 34% of patients were still insulin independent.

“For some patients, it will be a cure for Type 1 diabetes,” Hatipoglu said.

Hatipoglu was among the original researchers who worked on islet cell therapy during her tenure as medical director of the Pancreas and Islet Cell Transplant Program at University of Illinois Health at Chicago. Her involvement with the project continued after she joined UH.

She saw a tremendous effect in patients who participated in the Chicago trials.

“They don’t have to think about low sugars anymore,” she said. “This big burden is lifted.”

Dr. Betul Hatipoglu, chief of endocrinology at University Hospitals, second from left, attends a ribbon cutting for The UH Diabetes Center at MidTown in April with community and UH leaders. Patients with Type 1 diabetes and persistent hypoglycaemia can receive a new, life-changing treatment at UH.University Hospitals

‘Give it to everyone who qualifies’

Some people with Type 1 diabetes are unable to control their blood sugars by using insulin, and suffer from wide fluctuations from blood glucose that’s too high or too low, or hypoglycemia.

In Lantidra islet therapy, islet cells are extracted from a pancreas from a deceased donor, and turned into a liquid transfusion. The cells are injected into a particular vein that flows directly to the liver, where they implant and start producing insulin.

“The main goal with this treatment is to give a safe life to the patient without the risk of hypoglycaemia-induced, life-threatening episodes,” Hatipoglu said.

Patients sometimes need three infusions before they can stop taking insulin, and those receiving the donated cells must take immunosuppressive drugs to avoid having their bodies reject the cells.

Introducing islet cells into the liver is less challenging than reintroducing them to the pancreas, or performing a pancreas transplant, Hatipoglu said.

“Sometimes the pancreas is so small in these patients, from years of being attacked, it’s almost impossible to infuse (islet cells) back to the organ itself,” she said.

Because Type 1 diabetics have increased risk of a cardiovascular event during transplantation, whole organ transplantation is a poor option for some, she said.

Lantidra was approved by the Food and Drug Administration in 2023, but is only now becoming more widely available. UH began offering the treatment in late 2025.

UH is conducting screenings to find patients who are good candidates for the treatment. Candidates must have experienced dangerous episodes of low blood sugar at least once in the last year, and be a match with a donated pancreas.

Type 1 diabetics who are doing well on insulin are not candidates for this treatment.

Hatipoglu hopes the islet transfusion procedure can transform the lives of numerous Type 1 diabetes patients.

“You want to give it to everyone who qualifies,” she said.

https://www.cleveland.com/healthfit/2026/02/can-type-1-diabetes-be-cured-new-treatment-shows-promise-at-uh.html?outputType=amp

Wednesday, 18 February 2026

What Happens to Your Blood Sugar When You Eat Sardines Regularly

From health.com

  • Sardines are free of carbohydrates and rich in healthy fats which prevents blood sugar spikes.
  • Eating them regularly could help maintain stable blood sugar and lower your risk of developing type 2 diabetes.
  • Sardines also contain omega-3s and other nutrients that support heart health and reduce harmful inflammation.

The unique combination of nutrients in sardines makes the tiny fish a great choice if you're looking to manage blood sugar. In fact, eating them regularly could even lower your risk of developing type 2 diabetes and protect your heart health.

Eating Sardines Keeps Your Blood Sugar Stable

Blood sugar spikes are primarily driven by simple carbohydrates (or simple sugars). Sardines have no carbohydrates at all, so they won't raise your blood sugar after you eat them.

In addition, sardines may help modulate blood sugar spikes when you do eat carbohydrate-rich foods. That's because sardines contain other beneficial nutrients, including:

  • Protein: A can of sardines contains 22.6 grams of protein. This can slow gastric emptying, meaning that it takes more time for food to leave your stomach. Slower digestion is good for blood sugar, as any sugar you consume during a meal is released into the bloodstream more gradually.
  • Healthy fats: Sardines are one of the best sources of omega-3 fatty acids. These healthy, unsaturated fats can reduce inflammation, which otherwise interferes with the function of insulin. Insulin is a hormone that helps move glucose out of the bloodstream and into cells, keeping blood sugar levels where they should be. Plus, like protein, foods with healthy fats can slow digestion.
  • Magnesium and vitamin D: Sardines are a decent source of both magnesium and vitamin D. Evidence suggests these two micronutrients work together to help keep blood sugar levels steady, though most research has been done in supplements.
  • Taurine: This amino acid found in sardines helps improve how your body responds to insulin, which may lead to better blood sugar control.

Sardines May Help Lower Type 2 Diabetes Risk

          Sardines are good for blood sugar because they're rich in fats and protein, but contain no carbs.

jirkaejc / Getty Images



Keeping your blood sugar stable over time may help prevent type 2 diabetes. And research suggests sardines' blood sugar benefits could help people lower their risk of type 2 diabetes.

In a 2021 study, researchers followed 152 older adults with prediabetes, a condition where blood sugar levels are elevated but don't yet qualify as diabetes. For one year, half of the participants followed a diabetes-prevention diet, while the other half followed the same diet and also ate 200 grams (just over two cans) of sardines each week.

The sardine group saw major improvements—37% were at very high risk of diabetes when the study began, but that number dropped to 8% after a year. In the control group, the percentage of those at very high risk for diabetes fell from 27% to 22%.

The researchers concluded that sardines may be able to improve the body's response to insulin, suggesting that regular consumption of sardines can lower diabetes risk for those with prediabetes.

Sardines Are Also Linked to Heart Health Benefits

It's important to avoid diabetes and maintain healthy blood sugar if you want to protect your heart. But sardines can boost your heart health in other ways, too.

For one, sardines contain omega-3 fatty acids, which improve heart health by:

  • Lowering triglycerides: Omega-3s help manage high levels of triglycerides, which are fats in the body. Depending on your cholesterol levels, high triglycerides can contribute to fatty build-ups in the arteries which raise stroke and heart attack risk.
  • Tamping down inflammation: Over time, inflammation damages your blood vessels, allowing plaque—waxy deposits made of cholesterol, fat, and calcium—to build up in the arteries. This can restrict blood flow and raise the risk of a heart attack. Omega-3s may help prevent this with their anti-inflammatory properties.

In addition to omega-3s, sardines contain other nutrients that play various roles in supporting healthy heart function, including potassium, magnesium, zinc, calcium, and iron.

Because of these benefits, the American Heart Association recommends that people eat two servings of non-fried fish (which can include sardines) each week to lower their risk of heart disease.

Nutritional Breakdown

A standard, 3.75-ounce serving of canned sardines in oil provides the following:

  • Calories: 191
  • Protein: 22.6 grams
  • Fat: 10.5 grams
  • Carbohydrates: 0 grams
  • Calcium: 351 milligrams
  • Iron: 2.69 milligrams
  • Potassium: 365 milligrams
  • Magnesium: 35.9 milligrams
  • Selenium: 48.5 micrograms
  • Zinc: 1.2 milligrams
  • Vitamin B12: 8.22 micrograms
  • Vitamin D: 4.42 micrograms
  • Vitamin E: 1.88 milligrams
  • Sodium: 282 milligrams

Risks Related To Eating Sardines

Sardines are generally a healthy choice. However, there are a few things you should watch for if you're making them a regular part of your diet:

  • Sodium content: In canned varieties of sardines, sodium levels can be high—a standard can contains 282 milligrams of sodium. Adults should limit their sodium intake to 2,300 milligrams per day, so a can of sardines provides about 10% of that daily amount. Maintaining healthy sodium intake is particularly important if you're managing high blood pressure.
  • Heavy metals: Lead and mercury are sometimes found in fish. These metals accumulate gradually, so older, larger fish like sharks and swordfish have the highest levels. Sardines and other smaller options are much safer because they sit lower on the food chain. However, it can also depend on where they were caught, as some sardines from specific regions around the world have tested above safety limits.

7 Self-Care Tips for People With Type 2 Diabetes

From clevelandclinic.org

Prioritise your health by managing stress, strengthening your social connections and getting quality sleep 

Learning you have Type 2 diabetes (T2D) can be overwhelming. And so can learning how to manage the chronic condition — from how to check your blood sugar levels daily to how to make adjustments to the foods you eat.

So, how can you focus on your Type 2 diabetes self-care? Registered dietitian and diabetes educator Nicole Bruno, RD, LD, shares what you can do to ensure you’re taking care of your whole self.

7 self-care tips if you have Type 2 diabetes

“‘Self-care’ is an overarching term that’s all about prioritizing your health first,” explains Bruno. “Self-care isn’t just about your physical health — it’s also about your mental health.”

Bruno offers the following advice.

1. Manage stress

Stress affects everyone’s body. But when you have T2D, stress can actually increase your blood sugar.

“Cortisol, a stress hormone, can stimulate your liver to produce a little bit more glucose,” explains Bruno. “When your liver is pumping out that extra sugar in a stress response, and you’re insulin resistant, then that leads to higher blood sugars.”

There are many things you can do to manage or reduce your stress. Bruno suggests figuring out your key stress triggers (for example, an upcoming work presentation or arguing with your partner), and then looking for ways to manage stress around those situations.

Some simple, effective things you can do?

  • Practice box breathing.
  • Try meditation or yoga.
  • Take a walk around the block.
  • Go for a bike ride.
  • Read a book.

2. Focus on sleep

If you’ve ever had trouble falling asleep or getting the recommended seven to nine hours of sleep a night, you know that you can wake up cranky and tired.

“Sleep deprivation or inadequate sleep can result in high blood sugar level (hyperglycaemia),” shares Bruno. “Both inadequate and poor-quality sleep have similar symptoms to hyperglycaemia, including fatigue and hunger, so it’s important to keep an eye on your blood sugars and try to catch up on rest if you can.”

Also, think about when you’re going to bed.

“Research shows that poor sleep quality is associated with a 40% increased risk of developing Type 2 diabetes,” reports Bruno, “and that those with the evening chronotype (staying up later or waking up later) have higher odds for Type 2 diabetes, independent of sleep duration or quality.”

Even if you’re getting a good seven to nine hours of sleep, try to shift your bedtime schedule to be more appropriate. Going to bed a little bit earlier and waking up a little bit earlier helps align natural circadian rhythms and promotes quality sleep.

3. Monitor your blood sugar

Checking your blood sugar throughout the day — sometimes, three to four times — is part of your new normal. And it can feel like a lot to keep track of. But it doesn’t have to be an all-or-nothing approach.

“It’s important to monitor your blood sugar so you know what’s going on in your body,” clarifies Bruno. “If doing so consistently is really difficult for you, start with checking once a day or start with checking it a few times a week, so you can at least get in some sort of habit.”

Bruno also recommends setting alarms and talking with your healthcare provider about the best times each day for you to check.

4. Rethink what you eat

The foods you eat are key to managing your blood sugar levels. But if the idea of overhauling what you eat is daunting, don’t despair.

“Focus on making small, gradual changes,” recommends Bruno. “Are there ways you can start incorporating more fruits, vegetables, whole grains and lean proteins? Start by looking at what you currently eat and see which types of food you might be missing.”

The goal is to build a balanced meal that has:

  • Non-starchy vegetables, like broccoli or green beans
  • Lean proteins, like chicken or fish
  • Carbs, like whole grains or beans

Another way to make sure you’re eating a well-balanced diet is by meal planning and even keeping a food journal to give you an accurate picture.

“You want to aim for three meals a day, with four to five hours between those meals. Meal planning can help with this,” she adds. “And using some kind of food journal can help keep you accountable and more likely to stick with your nutrition goals.”

5. Get moving


Another important part of your self-care journey? Exercise.

“Exercise releases endorphins. Endorphins are your feel-good hormone,” says Bruno. “So, not only do you feel better, but exercise also lowers blood sugars.”

If you’re not sure where to begin, Bruno offers the following advice:

  • Start by taking baby steps. “You can start small and create a measurable goal,” she suggests. “Whether you exercise one day a week for five minutes, or it’s three days a week for 10 minutes, we want to be able to have a goal that’s measurable.” Starting gradually is going to help you feel more accomplished and more confident.
  • Refine your goals along the way. “By having small, attainable goals, you build up motivation to keep going,” explains Bruno. “Think about increasing duration or frequency.” For example, can you add five minutes to each workout session or add an additional workout day to your week?

And when it comes to what type of exercise counts, activities like running, biking, swimming and yoga can be great choices. But don’t overlook other tasks you might perform throughout your day.

“All movement counts. It could be walking your dog. It could be going to the grocery store more often and not doing store pickup,” illustrates Bruno. “It could be parking a little bit farther away when you go somewhere, so you’re getting some extra steps.”

6. Lean on your social connections

Talk to someone about how you’re feeling and any stress you’re trying to manage. In addition to turning to your friends and family for support, consider joining a support group.

“Social connections are going to be great for support, whether it’s a diabetes support group or even just having a family member or a friend you can talk to,” emphasizes Bruno. “When you isolate yourself, it’s easier to ignore a problem or how you’re feeling.”

The American Diabetes Association can be a good resource for finding a support group and additional resources.

Having a good support system can help you stick with your goals and focus on taking care of yourself. And if you’re overwhelmed by stress and anxiety, Bruno says talking to a mental health specialist can help you develop coping skills and techniques to manage your Type 2 diabetes.

7. Stay on top of your appointments

It may seem daunting to have so many appointments with your primary care doctor, your endocrinologist or even a cardiologist.

Bruno offers a few ways you can stay organized before and after appointments:

  • Use a calendar app or your medical system’s patient portal to track appointments and set reminders.
  • Schedule any follow-up appointments before you leave your doctor’s office.
  • Write out any questions beforehand.
  • Keep important info like a list of your medications or test results together in one space, document or folder that’s easily accessible.

Key takeaways

As you get more comfortable with managing your T2D, don’t forget to focus on yourself. Self-care habits can improve not only your mood, but also your overall health.

“Prioritising your self-care comes down to habits — and what we do every single day,” concludes Bruno. “But people get busy, and life happens. Be kind to yourself and make sure you’re focusing on building self-care habits that you can stick with.”

https://health.clevelandclinic.org/type-2-diabetes-self-care