Thursday, 31 October 2024

Do You Know The Signs Of Type 2 Diabetes?

From severnaparkvoice.com

November is Diabetes Awareness Month, highlighting a crucial health issue that affects more than 38 million Americans. According to the U.S. Centres for Disease Control and Prevention (CDC), 90% to 95% of those with diabetes have Type 2 diabetes, a chronic metabolic condition where the body doesn’t use insulin effectively, leading to elevated blood sugar levels.

Each year, 1.9 million new cases are diagnosed, yet more than 8 million Americans remain undiagnosed. If current trends persist, one in every three people born in the year 2000 will develop Type 2 diabetes in their lifetime.

What accounts for the high number of undiagnosed cases? The symptoms of Type 2 diabetes can develop gradually, leading many people to attribute cases to other factors. Additionally, a lack of awareness about these symptoms often prevents individuals from seeking a diagnosis and learning how to manage their condition effectively. During Diabetes Awareness Month, it’s important to raise awareness and encourage regular screenings to improve health outcomes.

Symptoms Of Type 2 Diabetes

Left untreated, Type 2 diabetes can lead to several complications, including cardiovascular disease, kidney disease, loss of vision, neuropathy, reduced circulation, loss of limbs, and more. That’s why you should see a physician as quickly as possible if you see any signs of Type 2 diabetes.

Here are some of the critical signs of Type 2 diabetes:

  • Frequent urination: High blood glucose causes your kidneys to filter out excess glucose, leading to increased urination, especially at night.
  • Increased thirst: Dehydration from frequent urination can cause persistent thirst, even if you're drinking more fluids than usual.
  • Unexplained weight loss: If your body cannot use glucose effectively due to insulin resistance, it may start breaking down fat and muscle for energy, causing weight loss.
  • Fatigue: Difficulty in using insulin for energy can leave you feeling persistently tired, especially after meals.
  • Blurred vision: High glucose levels can affect the lenses of your eyes, causing them to swell and leading to blurred vision.
  • Slow-healing wounds: High blood sugar affects circulation and nerve function, slowing the healing of cuts and wounds.
  • Frequent infections: Diabetes weakens the immune system, making you more prone to infections, such as those in the skin, gums and urinary tract.

When To See A Doctor

You should see a physician if you have one or more of these symptoms. Early detection and treatment of Type 2 diabetes can help you maintain a good quality of life and avoid serious complications. You can learn to manage Type 2 diabetes by making lifestyle changes, monitoring blood sugar levels, and taking medication, if necessary.

Recognizing the signs of Type 2 diabetes is the first step in managing the disease so you can lead a healthy and fulfilling life. 

Pedram Javanmard is an endocrinologist at Luminis Health with expertise in a wide range of endocrine-related diseases.

https://www.severnaparkvoice.com/stories/do-you-know-the-signs-of-type-2-diabetes,67053?

Sunday, 27 October 2024

Is Singapore winning the war against diabetes? What more can be done in fight against the chronic disease?

From malaysia.news.yahoo.com

SINGAPORE, Oct 26 — Singapore has recorded encouraging results since it launched war against diabetes in 2016 — with the the National Population Health Survey (NPHS) recording one in 12 Singaporeans having the chronic disease in 2022.

The numbers reflect a slight decline, from 8.8 per cent in 2017 to 8.5 per cent in 2022.

Experts however agree that much more had to be done, as the disease is not caused by a single factor but results from a combination of genetics, lifestyle, diet and environmental factors.

There are two main types of diabetes with type 1 diabetes generally associated with a genetic predisposition, where the body stops producing insulin and type 2 tends to be linked to lifestyle factors such as obesity and sedentary habits.

Both types of diabetes are serious and require ongoing care, but type 2 diabetes has a higher prevalence globally and in Singapore, and poses a significant public health challenge because of its link to long-term complications.

Novi Health co-founder Dr Sue-Anne Toh told Channel News Asia: “We didn't go up in terms of prevalence, and we even went down slightly. While this is a promising sign, it is still too early to come to a definitive conclusion.

“It's definitely in the right direction. Given that globally (the prevalence rates) are going up, we have been able to keep ours the same or even slightly lower, which is good,”

Diabetes, endocrinology and internal medicine consultant Dr Kevin Tan however reminded that managing type 2 diabetes remains difficult, as it involves complex interactions between biology, genetics and lifestyle choices.

National University of Singapore (NUS) Saw Swee Hock School of Public Health (SSHSPH) assistant Professor Ian Ang agreed, saying that to prevent people from getting diabetes in the first place, efforts have to take place outside of healthcare institutions, and get involved in people's daily lives.

Since 2016, Singapore has implemented several initiatives targeted at various risk factors for the disease, with one being obesity.

The National Population Health Survey (NPHS) in 2022 reported that the prevalence of obesity among Singaporeans steadily increased over the past decade, from 8.6 per cent in 2013 to 11.6 per cent in 2022 — prompting the government to promote regular exercise, healthy dietary habits, early disease detection and better disease treatment.

Even before it shifted gears on dealing with diabetes, the Health Promotion Board (HPB) had launched its Healthier Choice Symbol (HCS) in 2001, slapping its symbol on packaged food items to note healthier alternatives containing less salt, sugar or fat than other similar products.

HPB also marked certain foods, such as some cereals, with a label to indicate that they had a low glycaemic index (GI) which measures how quickly it raises blood sugar levels after consumption.

From 2016 however, the programme was expanded, with more foods — including convenience meals, legumes, nuts and seeds — with low GI marked out with the symbol to be more easily identifiable for consumers.

According to a Ministry of Health (MOH) report, as a result of this labelling programme, the market share of HCS products increased from 18 per cent in 2016 to 25.4 per cent in 2018 across 100 categories.

These include lower-sugar packaged beverages and sauces and wholegrain versions of rice, noodles and bread.

In December 2022, MOH also introduced Nutri-Grade labelling requirements and set advertising prohibitions for pre-packaged beverages, extending to freshly-prepared drinks last year.

The Nutri-Grade system labels beverages with grades ranging from A to D, with D being the unhealthiest.

Since then, the median sugar level of pre-packed Nutri-Grade drinks has gone down from 7.1 per cent in 2017 to 4.6 per cent in September 2023, and about six in 10 beverage outlets dealing with freshly prepared drinks are now offering less sweet choices by default.

In addition to Nutri-Grade system labelling, HPB launched the “Siu Dai by default” movement in the same month to complement the Nutri-Grade labelling requirement where beverage sellers who join the movement make their drinks with less sugar by default.

SSHSPH dean Professor Yik Ying Teo said that he counted the measure as a “major win” in the fight against diabetes.

“By labelling A, B, C or D on beverages as well as now on bubble tea and freshly prepared drinks, that has compelled more consumers to shift their preferences or shift their choices to healthier grades of A and B.

“All this has increased the awareness amongst the people that having too much sugar is not good for you.”

Allium Healthcare senior principal dietician Mary-ann Chiam said the challenge however lay in turning that awareness into long-term behavioural changes.

“Food habits are deeply ingrained and sustained.

“The progress is promising, but there's still work to be done.”

She said it is “preferable to start young,” highlighting HPB's efforts to eliminate sweet juices and sugary cereals from childcare centres and kindergartens aimed at fostering a lasting aversion to sweetened beverages, encouraging healthier habits from an early age.

Apart promoting healthy eating habits, another key initiative in the fight against diabetes is the Screen for Life programme, which encourages Singaporeans to undergo regular health screenings.

Under the scheme, Singapore residents aged 40 years and above can get themselves checked for chronic diseases such as diabetes, hypertension and hypercholesterolemia at a subsidised fee.

Singaporean adults can also use a self-administered diabetes risk assessment tool to determine whether they are at risk.

Experts are highly supportive of encouraging early screening, noting that the timely detection of diabetes can significantly improve long-term health outcomes by enabling early intervention and better disease management.​

Harmony Thyroid Endocrinology and Diabetes Centre founder and senior consultant endocrinologist Dr Vikram Sonawane said many type 2 diabetes cases are left undiagnosed for a long time because the condition tends to be asymptomatic in its early stages.

“This is why I always advise my patients with risk factors, especially those above 40 years old, to undergo routine screening for diabetes despite feeling perfectly well.”

In another move to encourage a more active lifestyle, HPB's National Steps Challenge, launched in 2015, was met with overwhelming success, with 1.7 million participants.

The challenge is a reward-based physical activity designed to encourage people to stay active: The more people walk, run or move in their daily lives, the more rewards they will get.

Since 2023, eligible Healthy 365 users have been auto-enrolled into the National Steps Challenge.

This year, HPB will be introducing a new set of features and milestone-based challenges on the Healthy 365 app.

It has been eight years since the launch of the war on diabetes, and progress has been slow — and experts caution that it may take more time before its impact can be fully evaluated as a long-term success.​

“Effects for chronic disease prevention initiatives will always take decades before the effects and expected trends can be analysed,” said Ang.

Diabetes consultant and past president of Diabetes Singapore Dr Tan said the war will not be won conclusively.

“We've seen shifts in people's habits, consumer buying patterns, industry buy-in and improved disease outcomes.”

Teo agrees saying it can be hard to determine the success of the number of people with diabetes as this number will always rise, given the ageing population.

“Diabetes is a long-term disease, so it's very difficult to attribute that some of these policy changes are the reason that diabetes rates such as prevalence rate have remained stable or fallen.”

Suggesting a more holistic measure of success including consumption patterns and how the F&B industry has responded to measures, other signs of winning the war would be if fewer people are suffering from complications from diabetes, such as vision problems or cardiovascular disease, he said.

“If there have been fewer and fewer people with such complications over the years, then it means that people are now much more aware that they have diabetes and are making the right effort to control the progression of diabetes.”

Tan noted that major lower extremity amputations have fallen from 116 to 66.3 per 100,000 patients from 2015 to 2019.

Lower body amputations signify a more severe complication of diabetes and mean that the disease has progressed to an advanced stage.Singaporean health experts agree that much more has to be done as diabetes is not caused by a single factor but results from a combination of genetics, lifestyle, diet and environmental factors. 
— AFPSingaporean health experts agree that much more has to be done as diabetes is not caused by a single factor but results from a combination of genetics, lifestyle, diet and environmental factors. — AFP

So what more can Singapore do?

One suggestion is to look to Chile, which slaps mandatory warning labels on products with high salt, sugar, saturated fat and calories on the front of the packaging, which has effectively changed consumer behaviour.

Researchers from the University of Chile and the University of North Carolina, Chapel Hill, found that Chileans bought 37 per cent less sugar, 22 per cent less sodium, 16 per cent less saturated fat, and 23 per cent fewer total calories three years after the labelling system was introduced.

The Chilean labelling system is considered more user-friendly, with messages on the front and back of certain packaged foods clearly detailing their high sugar, fat or calorie content.

Other suggestions include a sugar tax or more stringent mandatory food labelling laws could be considered too.

Over 50 countries have implemented taxes on sugar-sweetened beverages to date.

Notable examples include Mexico, which implemented such as tax in 2014, resulting in an 11 per cent increase in prices for sweetened beverages.

By 2016, Mexican consumers were buying 37 per cent fewer sweetened beverages, and researchers have estimated that the sugar tax has prevented 239,900 cases of obesity, 39 per cent of whom would have been children.

In the United Kingdom, a sugar tax called the Soft Drinks Industry Levy was introduced in 2018, so that drinks that contained high levels of sugar were taxed more.

This led manufacturers to reformulate their drink to reduce sugar levels in sweetened beverages.

Between 2015 and 2019, the percentage of drinks in supermarkets with sugar content of more than 5g per 100 ml fell from 49 per cent to 15 per cent.

And four years after the tax was introduced, the sugar content of the drinks subject to the tax had reduced by 43.7 per cent.

Toh however emphasised that diabetes is a disease that can be largely controlled by individual choices.

“Individuals need to take ownership of their own health. It all comes down to lifestyle decisions we make on a daily basis, and we cannot rely on the government alone.”

https://malaysia.news.yahoo.com/singapore-winning-war-against-diabetes-023753359.html 

Saturday, 26 October 2024

For type 2 diabetes, focusing on when you eat – not what – can help control blood sugar

From theconversation.com

By Evelyn Parr and Brooke Devlin

Type 2 diabetes affects 1.2 million Australians and accounts for 85-90% of all diabetes cases. This chronic condition is characterised by high blood glucose (sugar) levels, which carry serious health risks. Complications include heart disease, kidney failure and vision problems.

Diet is an important way people living with type 2 diabetes manage blood glucose, alongside exercise and medication. But while we know individualised, professional dietary advice improves blood glucose, it can be complex and is not always accessible. 

Our new study looked at the impact of time-restricted eating – focusing on when you eat, rather than what or how much – on blood glucose levels.

We found it had similar results to individualised advice from an accredited practising dietitian. But there were added benefits, because it was simple, achievable, easy to stick to – and motivated people to make other positive changes.

What is time-restricted eating?

Time-restricted eating, also known as the 16:8 diet, became popular for weight loss around 2015. Studies have since shown it is also an effective way for people with type 2 diabetes to manage blood glucose.

Time-restricted eating involves limiting when you eat each day, rather than focusing on what you eat. You restrict eating to a window during daylight hours, for example between 11am and 7pm, and then fast for the remaining hours. This can sometimes naturally lead to also eating less.

Participants in our study could still share meals with family, as long as it was within a nine-hour window finishing at 7pm. Kitreel/Shutterstock

Giving your body a break from constantly digesting food in this way helps align eating with natural circadian rhythms. This can help regulate metabolism and improve overall health.

For people with type 2 diabetes, there may be specific benefits. They often have their highest blood glucose reading in the morning. Delaying breakfast to mid-morning means there is time for physical activity to occur to help reduce glucose levels and prepare the body for the first meal.

How we got here

We ran an initial study in 2018 to see whether following time-restricted eating was achievable for people with type 2 diabetes. We found participants could easily stick to this eating pattern over four weeks, for an average of five days a week.

Importantly, they also had improvements in blood glucose, spending less time with high levels. Our previous research suggests the reduced time between meals may play a role in how the hormone insulin is able to reduce glucose concentrations.

Other studies have confirmed these findings, which have also shown notable improvements in HbA1c. This is a marker in the blood that represents concentrations of blood glucose over an average of three months. It is the primary clinical tool used for diabetes.

However, these studies provided intensive support to participants through weekly or fortnightly meetings with researchers.

While we know this level of support increases how likely people are to stick to the plan and improves outcomes, it is not readily available to everyday Australians living with type 2 diabetes.

What we did

In our new study, we compared time-restricted eating directly with advice from an accredited practising dietitian, to test whether results were similar across six months.

We recruited 52 people with type 2 diabetes who were currently managing their diabetes with up to two oral medications. There were 22 women and 30 men, aged between 35 and 65.

Participants were randomly divided into two groups: diet and time-restricted eating. In both groups, participants received four consultations across the first four months. During the next two months they managed diet alone, without consultation, and we continued to measure the impact on blood glucose.

In the diet group, consultations focused on changing their diet to control blood glucose, including improving diet quality (for example, eating more vegetables and limiting alcohol).

In the time-restricted eating group, advice focused on how to limit eating to a nine-hour window between 10am and 7pm.

Over six months, we measured each participant’s blood glucose levels every two months using the HbA1c test. Each fortnight, we also asked participants about their experience of making dietary changes (to what or when they ate).

What we found

We found time-restricted eating was as effective as the diet intervention.

Both groups had reduced blood glucose levels, with the greatest improvements occurring after the first two months. Although it wasn’t an objective of the study, some participants in each group also lost weight (5-10kg).

When surveyed, participants in the time-restricted eating group said they had adjusted well and were able to follow the restricted eating window. Many told us they had family support and enjoyed earlier mealtimes together. Some also found they slept better.

After two months, people in the time-restricted group were looking for more dietary advice to further improve their health.

Those in the diet group were less likely to stick to their plan. Despite similar health outcomes, time-restricted eating seems to be a simpler initial approach than making complex dietary changes.

Is time-restricted eating achievable?

The main barriers to following time-restricted eating are social occasions, caring for others and work schedules. These factors may prevent people eating within the window.

However, there are many benefits. The message is simple, focusing on when to eat as the main diet change. This may make time-restricted eating more translatable to people from a wider variety of socio-cultural backgrounds, as the types of foods they eat don’t need to change, just the timing.

Many people don’t have access to more individualised support from a dietitian, and receive nutrition advice from their GP. This makes time-restricted eating an alternative – and equally effective – strategy for people with type 2 diabetes.

People should still try to stick to dietary guidelines and prioritise vegetables, fruit, wholegrains, lean meat and healthy fats.

But our study showed time-restricted eating may also serve as stepping stone for people with type 2 diabetes to take control of their health, as people became more interested in making diet and other positive changes.

Time-restricted eating might not be appropriate for everyone, especially people on medications which don’t recommend fasting. Before trying this dietary change, it’s best speak to the healthcare professional who helps you manage diabetes.

https://theconversation.com/for-type-2-diabetes-focusing-on-when-you-eat-not-what-can-help-control-blood-sugar-241472 

Thursday, 24 October 2024

People with diabetes should avoid 7 fruits that can cause blood sugar to spike

From getsurrey.co.uk

For people with diabetes, certain fruits are considered "dangerous" as they have a high glycaemic index, which can cause blood sugar levels to rise sharply

Fruit is a staple of any balanced diet, packed with essential vitamins and minerals and typically low in calories. However, certain fruits are deemed "dangerous" for those living with diabetes due to their high glycaemic index.

The NHS reports that over 4.9 million people in the UK are affected by this lifelong condition, which results in excessively high blood sugar levels as the body struggles to break down glucose effectively. Diabetes comes in two forms - type 1 and 2.

Type 1 arises when insulin-producing cells, which regulate blood sugar levels, are destroyed by the body. Type 2 diabetes, the more prevalent form affecting 90% of adult sufferers in the UK, is often linked to obesity or insufficient physical activity.

                                                   Some fruits should not be eaten by people with diabetes 

While a variety of fruits should be included in a diabetic's diet, health experts caution against those with a higher glycaemic index (GI). The GI is a rating system indicating how rapidly foods containing carbohydrates impact your blood sugar level when consumed alone.

As Diabetes.co.uk explains: "High GI foods break down very quickly causing blood glucose levels to rise sharply. People with diabetes refer to sharp rises in blood sugar levels as 'spikes' in blood sugar.

"Furthermore, for those who produce their own insulin, high GI foods can force the body to try to produce a surge of insulin to counteract the fast-acting carbohydrates and a common consequence of this is a feeling of hunger within two to three hours, which can leave the dieter craving more food."

It warns: "For people with diabetes, this can be particularly dangerous as the ability of the body to control blood glucose levels is reduced or non-existent."

High GI fruits diabetics should avoid include:

  • bananas
  • oranges
  • mangoes
  • grapes
  • raisins
  • dates
  • pears

On the other hand, lower GI foods are recommended such as: plums

  • berries
  • kiwi fruit
  • grapefruit

The NHS advises that while low GI foods are beneficial for diabetes patients, maintaining a balanced diet is also crucial. They said: "Some low GI foods, such as wholegrain foods, fruit, vegetables, beans and lentils, are foods we should eat as part of a healthy, balanced diet. However, using the glycaemic index to decide whether foods or combinations of foods are healthy can be misleading.

"Foods with a high GI are not necessarily unhealthy and not all foods with a low GI are healthy. For example, watermelon and sometimes parsnips are high GI foods, while chocolate cake has a lower GI value."

Diabetes.co.uk has shed light on the benefits of a low glycemic index (GI) diet, noting: "As low GI foods tend to break down more slowly, they are less likely to cause a rapid increase in blood sugar levels compared to high GI foods and therefore they are a better option for keeping stable blood glucose levels."

The guidance further mentioned: "Favouring low GI foods over high GI foods leaves you feeling more satisfied over a longer period of time, and less likely to feel hungry before the next meal."

Also highlighted were typical high GI foods to avoid such as: Sugar and sugary foods

  • sugary soft drinks
  • white bread
  • potatoes
  • white rice

Even an occasional 30-minute exercise session reduces type 2 diabetes risk factors, study finds

From medicalxpress.com

Researchers at Centro per le Malattie Endocrine e Metaboliche, Italy, have found that a single 30-minute aerobic exercise session significantly reduced 1-hour post-load plasma glucose levels and improved insulin sensitivity in young, healthy adults. Participants showed improvements in glucose metabolism following a single bout of physical activity, indicating potential benefits in managing and preventing type 2 diabetes.

Physical exercise is clinically recognized for improving  and insulin sensitivity, critical factors in preventing type 2 diabetes. While the research link is typically focused on the long-term effects of regular physical activity, the current study examined the immediate impact of a single aerobic exercise session on glucose levels.

                                                                                    Credit: Unsplash/CC0 Public Domain

In the study, "A single bout of  improves 1-hour post-load plasma glucose in healthy young adults," published in the Journal of Endocrinological Investigation, researchers tested the effects of a single 30-minute aerobic exercise session on glucose metabolism in healthy young adults. They used a 1-hour post-load glucose test as prior studies have shown that it is a strong predictor of future diabetes risk.

A total of 32 participants, aged 20 to 35, were recruited for the study. None had a history of diabetes or competitive sports involvement, and none were on medication. All underwent an  (OGTT) at baseline, followed by a light jogging session (60–65% of their VO2max).

A second OGTT was administered 24 hours after the exercise to assess changes in fasting glucose, 1-hour post-load glucose, and insulin levels. Insulin sensitivity was also evaluated using surrogate indices such as the Matsuda and QUICKI indexes.

Fasting glucose levels decreased from 82.8 mg/dL to 78.5 mg/dL, and 1-hour post-load glucose dropped from 122.8 mg/dL to 111.8 mg/dL after exercise. Insulin levels at the 1-hour mark also fell significantly from 57.4 µUI/ml to 43.5 µUI/ml. Insulin sensitivity improved, as indicated by increases in the Matsuda index from 7.79 to 9.02 and the QUICKI index from 0.36 to 0.38. The HOMA-IR index, a measure of insulin resistance, decreased from 1.51 to 1.28.

These positive effects on glucose metabolism and , just 24 hours after a single exercise session, suggest that even occasional physical activity could significantly contribute to reducing the risk of type 2  through immediate improvements in glucose control.

More information: Simona Moffa et al, A single bout of physical exercise improves 1-hour post-load plasma glucose in healthy young adults, Journal of Endocrinological Investigation (2024). DOI: 10.1007/s40618-024-02438-8

https://medicalxpress.com/news/2024-10-occasional-minute-session-diabetes-factors.html 

Wednesday, 23 October 2024

People with Type 2 diabetes may be able to discontinue medication after eating a low-carb diet, new research suggests

From uab.edu

New research from the University of Alabama at Birmingham, published in the Journal of Clinical Endocrinology & Metabolism, shows that adults with Type 2 diabetes who follow a low-carbohydrate diet might experience improvements in their beta-cell function, potentially helping them manage their condition more effectively and potentially reduce or eliminate the need for medication.

More than 38 million Americans have diabetes, and more than 90 percent of them have Type 2 diabetes. Type 2 diabetes usually presents in people who are 45 or older. However, it is becoming more common in children, teenagers and young adults too.

People with Type 2 diabetes have a compromised beta-cell response to blood sugar, possibly due in part to eating too many carbohydrates. Beta-cell failure or insufficiency on top of insulin resistance is responsible for the development and progression of Type 2 diabetes.

“This study shows that people with Type 2 diabetes on a low-carbohydrate diet can recover their beta-cells, an outcome that cannot be achieved with medication,” said lead study author Barbara Gower, Ph.D., chair of the UAB Department of Nutrition Sciences. “People with mild Type 2 diabetes who reduce their carbohydrate intake may be able to discontinue medication and enjoy eating meals and snacks that are higher in protein and meet their energy needs.”

The study compared two groups of adults with Type 2 diabetes: one group followed a low-carb diet, and the other followed a high-carb diet. Researchers wanted to see how these diets affected beta-cell function and insulin secretion.

The study found that the low-carb diet improved beta-cell function and insulin secretion, even after accounting for any weight loss. This means the benefits of the low-carb diet were not just because people lost weight.

Participants were asked to stop taking their diabetes medication before the study started so any changes in their health could be linked to the diet.

All participants were given their meals as part of the study. The low-carb diet was low in carbs and high in fat, while the high-carb diet was high in carbs and low in fat.

The researchers found those on a low-carbohydrate versus a high-carbohydrate diet saw improvements in the acute and maximal beta-cell responses that were twofold and 22 percent greater, respectively. Within each race group, Black adults on a low-carbohydrate diet saw 110 percent greater improvements in the acute beta-cell response and White adults had improvements in the maximal beta-cell response that were 48 percent greater than their respective counterparts on the high-carbohydrate diet.

“Further research is needed to determine if a low-carbohydrate diet can restore beta-cell function and lead to remission in people with Type 2 diabetes,” Gower said.

https://www.uab.edu/news/research/item/14406-people-with-type-2-diabetes-may-be-able-to-discontinue-medication-after-eating-a-low-carb-diet-new-research-suggests 

Tuesday, 22 October 2024

New Diabetes Treatment Eliminates Need for Insulin in Most Type 2 Patients

From extremetech.com 

The experimental therapy takes just a few weeks and removed insulin from the equation for 86% of trial participants

A new form of treatment for Type 2 diabetes could eliminate the need for insulin injections. In a recent trial, 86% of participants—who spanned a wide range of ages and body mass index (BMI) placements—were able to forgo insulin after just a few weeks of the novel therapy.

Presented last week at United European Gastroenterology's annual conference, the treatment combines an existing injectable drug with a new procedure called re-cellularization via electroporation therapy, or ReCET. The injectable, called semaglutide, is used exclusively with Type 2 diabetes patients to mimic the effects of the GLP-1 hormone, which naturally regulates the body's blood sugar levels. ReCET meanwhile occurs via endoscopy—a procedure that involves snaking a thin tube down a sedated patient's oesophagus—and delivers small electrical pulses to the stomach's mucosal lining. These pulses reportedly improve the body's sensitivity to endogenous, or naturally-occurring, insulin.

                                                    Credit: A. Martin UW Photography/Moment via Getty Images

Celine Busch, a PhD candidate and research associate at Amsterdam University Medical Centre, led a trial last year that utilized both of these treatments. The trial involved 14 patients aged 28 to 75. First, each participant underwent ReCET; after, they were required to stick to a strict liquid diet for two weeks. Participants then received 1 milligram of semaglutide per week as they readjusted to their typical diets.

According to a paper for the journal Gastrointestinal Endoscopy, 12 of the 14 participants were able to stay insulin-free past the 6-month and 12-month follow-ups. All 12 of these participants were shown to maintain glycaemic control, meaning their bodies were capable of keeping blood glucose levels within a healthy range. Only one of the 14 participants reacted negatively to the semaglutide and was unable to receive the required dosage; nobody else experienced negative side effects. 

Though semaglutide is an injectable drug, its use within the context of this particular therapy requires far less "patient compliance" than insulin. Insulin-dependent Type 2 diabetes patients—that is, patients who are unable to control the condition via diet or oral medication—typically inject insulin a few times per week, and missing a dose can be life-threatening. Semaglutide could reduce the amount of work required on the patient's part to keep their blood glucose at a healthy level.

Busch and her colleagues are currently testing the treatment with a new group of participants. In this controlled trial, called EMINENT-2, the team will incorporate a sham procedure that tests the efficacy of semaglutide with a placebo.

https://www.extremetech.com/science/new-diabetes-treatment-eliminates-need-for-insulin-in-most-patients